1186334-89-3Relevant academic research and scientific papers
Indazolylpyrazolopyrimidine as highly potent B-Raf inhibitors with in vivo activity
Wang, Xiaolun,Berger, Dan M.,Salaski, Edward J.,Torres, Nancy,Dutia, Minu,Hanna, Cilien,Hu, Yongbo,Levin, Jeremy I.,Powell, Dennis,Wojciechowicz, Donald,Collins, Karen,Frommer, Eileen,Lucas, Judy
supporting information; experimental part, p. 7874 - 7878 (2011/01/12)
Novel indazolylpyrazolo[1,5-a]pyrimidine analogues have been prepared and found to be extremely potent type I B-Raf inhibitors. The lead compound shows good selectivity against a panel of 60 kinases, possesses a desirable pharmacokinetic profile, and demonstrates excellent in vivo antitumor efficacy in B-Raf mutant xenograft models.
Dramatic effect of solvent hydrogen bond basicity on the regiochemistry of SNAr reactions of electron-deficient polyfluoroarenes
Wang, Xiaolun,Salaski, Edward J.,Berger, Dan M.,Powell, Dennis
supporting information; experimental part, p. 5662 - 5664 (2010/03/01)
[Chemical Equation Presented] It was found that solvent hydrogen bond basicity (SHBB) significantly affects the regiochemistry of the SNAr reaction between secondary amines and activated polyfluoroarenes. A plausible mechanism involving a six-m
BRIDGED, BICYCLIC HETEROCYCLIC OR SPIRO BICYCLIC HETEROCYCLIC DERIVATIVES OF PYRAZOLO[1,5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF
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Page/Page column 114-115, (2009/10/21)
Compounds of formula A: Formula (1) pharmaceutically acceptable salts thereof are described, which selectively inhibit Raf kinase activity and are useful for treating disorders mediated by Raf kinases.
