1186334-89-3

Basic information

• Product Name: tert-butyl (1S,4S)-5-(4-acetyl-3,5-difluorophenyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate
• Synonyms: tert-butyl (1S,4S)-5-(4-acetyl-3,5-difluorophenyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate
• CAS NO: 1186334-89-3
• Molecular Weight: 352.381
• Mol File: 1186334-89-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: tert-butyl (1S,4S)-5-(4-acetyl-3,5-difluorophenyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (1S,4S)-5-(4-acetyl-3,5-difluorophenyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate(1186334-89-3)
• EPA Substance Registry System: tert-butyl (1S,4S)-5-(4-acetyl-3,5-difluorophenyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate(1186334-89-3)

Safety Data

• Hazardous Substances Data: 1186334-89-3(Hazardous Substances Data)

Upstream product

• 51788-77-3 1-(2,4,6-trifluorophenyl)ethan-1-one 
• 113451-59-5 (1S,4S)-2,5-Diaza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester 

Downstream Products

• 1186334-90-6 (1S,4S)-tert-butyl 5-(4-((E)-3-(dimethylamino)acryloyl)-3,5-difluorophenyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate 

Relevant articles and documents

Indazolylpyrazolopyrimidine as highly potent B-Raf inhibitors with in vivo activity

Novel indazolylpyrazolo[1,5-a]pyrimidine analogues have been prepared and found to be extremely potent type I B-Raf inhibitors. The lead compound shows good selectivity against a panel of 60 kinases, possesses a desirable pharmacokinetic profile, and demonstrates excellent in vivo antitumor efficacy in B-Raf mutant xenograft models.

BRIDGED, BICYCLIC HETEROCYCLIC OR SPIRO BICYCLIC HETEROCYCLIC DERIVATIVES OF PYRAZOLO[1,5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF

Compounds of formula A: Formula (1) pharmaceutically acceptable salts thereof are described, which selectively inhibit Raf kinase activity and are useful for treating disorders mediated by Raf kinases.