1186335-67-0

Basic information

• Product Name: 3,4,5,6-tetrachloro-N-(4-[(1E)-2-(3,4-dimethoxyphenyl)ethenyl]phenyl)phthalimide
• Synonyms: 3,4,5,6-tetrachloro-N-(4-[(1E)-2-(3,4-dimethoxyphenyl)ethenyl]phenyl)phthalimide
• CAS NO: 1186335-67-0
• Molecular Weight: 523.199
• Mol File: 1186335-67-0.mol

Chemical Properties

• CAS DataBase Reference: 3,4,5,6-tetrachloro-N-(4-[(1E)-2-(3,4-dimethoxyphenyl)ethenyl]phenyl)phthalimide(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4,5,6-tetrachloro-N-(4-[(1E)-2-(3,4-dimethoxyphenyl)ethenyl]phenyl)phthalimide(1186335-67-0)
• EPA Substance Registry System: 3,4,5,6-tetrachloro-N-(4-[(1E)-2-(3,4-dimethoxyphenyl)ethenyl]phenyl)phthalimide(1186335-67-0)

Safety Data

• Hazardous Substances Data: 1186335-67-0(Hazardous Substances Data)

Upstream product

• 117-08-8 tetrachlorophthalic anhydride 

Downstream Products

• 1186335-82-9 (E)-4,5,6,7-tetrachloro-N-{4-[2-(3,4-dihydroxyphenyl)ethenyl]phenyl}phthalimide 

Relevant articles and documents

Separation of α-glucosidase-inhibitory and liver X receptor-antagonistic activities of phenethylphenyl phthalimide analogs and generation of LXRα-selective antagonists

Liver X receptor (LXR) α/β dual agonists are candidate medicaments for the treatment of metabolic syndrome, because their biological actions include increasing cholesterol efflux mediated by LXRβ. However, their clinical application is currently limited by their enhancing effect on triglyceride (TG) synthesis mediated by LXRα. Combination of an LXRα-selective antagonist with an LXRα/β dual agonist may overcome this disadvantage. In the present work, structural development studies of phenethylphenyl phthalimide 9, which possesses LXRα/β dual-antagonistic activity and α-glucosidase-inhibitory activity, led to the LXRα-selective antagonist 23f. Specific α-glucosidase inhibitors were also obtained.