1186337-48-3Relevant academic research and scientific papers
Application of a 3,3-diphenylpentane skeleton as a multi-template for creation of HMG-CoA reductase inhibitors
Hosoda, Shinnosuke,Matsuda, Daisuke,Tomoda, Hiroshi,Hashimoto, Mariko,Aoyama, Hiroshi,Hashimoto, Yuichi
scheme or table, p. 4228 - 4231 (2010/05/02)
Based on our hypothesis that the 3,3-diphenylpentane (DPP) skeleton is useful as a multi-template for creation of various biologically active compounds and acts as a steroid skeleton substitute, we designed and synthesized novel HMG-CoA reductase inhibitors with a DPP skeleton. Among them, sodium (E,3R,5S)-7-(2-(4-fluorophenyl)-4-(3-phenylpentan-3-yl)phenyl)-3,5-dihydroxy-hept-6-enoate showed potent HMG-CoA reductase-inhibitory activity comparable with that of clinically useful mevastatin.
