1186384-41-7

Upstream product

• 936012-06-5 C₁₆H₁₇NO₄S 
• 875535-33-4 (3R)-3-phenyl-3-(4-toluenesulfonyl)aminopropionitrile 
• 875438-77-0 (2S)-O-(p-toluenesulfonyl)-N-(p-toluenesulfonyl)phenylglycinol 
• 20989-17-7 (2S)-2-phenylglycinol 
• 2935-35-5 (S)-2-phenylglycine 
• 1079366-88-3 (R)-2-phenyl-1-(toluene-4-sulfonyl)azetidine 
• 627-18-9 1-bromo-3-propanol 
• 936011-91-5 (S)-2-phenyl-1-tosylazetidine 

Downstream Products

• 1186384-35-9 (R)-2-phenyl-5-tosyl-1,5-oxazocane 

Relevant academic research and scientific papers

Metal-free one-pot synthesis of 2-substituted and 2,3-disubstituted morpholines from aziridines

The metal-free synthesis of 2-substituted and 2,3-disubstituted morpholines through a one-pot strategy is described. A simple and inexpensive ammonium persulfate salt enables the reaction of aziridines with halogenated alcohols to proceed via an SN2-type ring opening followed by cyclization of the resulting haloalkoxy amine.

Enantioselective syntheses of morpholines and their homologues via S N2-type ring opening of aziridines and azetidines with haloalcohols

(Chemical Equation Presented) A highly regio- and stereoselective strategy for the syntheses in high yield and enantioselectivity of a variety of substituted nonracemic morpholines and their homologues is described. The reaction proceeds via an SN2-type ring opening of activated aziridines and azetidines by suitable halogenated alcohols in the presence of Lewis acid followed by base-mediated intramolecular ring closure of the resulting haloalkoxy amine.