1186387-09-6Relevant articles and documents
Identification of substituted pyrazolo[1,5-a]quinazolin-5(4H)-one as potent poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors
Orvieto, Federica,Branca, Danila,Giomini, Claudia,Jones, Philip,Koch, Uwe,Ontoria, Jesus M.,Palumbi, Maria Cecilia,Rowley, Michael,Toniatti, Carlo,Muraglia, Ester
scheme or table, p. 4196 - 4200 (2010/04/02)
A novel series of pyrazolo[1,5-a]quinazolin-5(4H)-one derivatives proved to be a potent class of PARP-1 inhibitors. An extensive SAR around the 3-position of pyrazole in the scaffold led to the discovery of amides derivatives as low nanomolar PARP-1 inhibitors.
