1186398-39-9Relevant articles and documents
Potent agonists of the Hedgehog signaling pathway
Brunton, Shirley A.,Stibbard, John H.A.,Rubin, Lee L.,Guicherit, Oivin M.,Kruse, Lawrence I.,Price, Stephen,di Lucrezia, Raffaella,MacKinnon, Colin H.,Avery, Alaric,Park, Yvonne,Buxton, Danielle,Boyd, Edward A
scheme or table, p. 4308 - 4311 (2010/04/26)
A family of biaryl substituted 1,4-diaminocyclohexanamides of 3-chlorobenzothiophene-2-carboxylic acid is reported as picomolar modulators of Hedgehog protein function. SAR for the 1,4-diaminocyclohexane group is shown to be exquisitely sensitive to subst
