118644-66-9

Upstream product

• 1696-20-4 4-acetylmorpholine 
• 100-47-0 benzonitrile 
• 81836-50-2 (Z)-3-Chloro-3-morpholin-4-yl-1-phenyl-propenone 
• 10562-42-2 3,3-dichloro-1-phenyl-propenone 

Relevant academic research and scientific papers

KOtBu-promoted synthesis of multi-substituted 4-aminopyrimidines from benzonitriles and aliphatic amides

Multi-substituted 4-aminopyrimidines have been prepared from commercially-available benzonitriles and aliphatic amides under transition-metal-free conditions. With KOtBu as the only promoter, the desired pyrimidines were isolated in moderate to excellent yields.

Cyclization Reactions of 2-Acyl-1-chloro-enamines with Thioamide Functional Compounds: Alternative Access to the 1,3-Thiazine and 1,3-Oxazine Series

2-Acyl-1-chloro-enamines 2 react with thioureas to 2,6-diamino-1,3-thiazinium salts 3, following to usual transformation mode of 1-heterosubstituted acylvinylchlorides A.On the other hand the reaction of 2 with thiobenzamide preferably leads to 4-amino-1,