1186467-83-3Relevant academic research and scientific papers
Synthesis and anticancer evaluation of spermatinamine analogues
Moosa, Basem A.,Sagar, Sunil,Li, Song,Esau, Luke,Kaur, Mandeep,Khashab, Niveen M.
, p. 1629 - 1632 (2016)
Spermatinamine was isolated from an Australian marine sponge, Pseudoceratina sp. as an inhibitor of isoprenylcysteine carboxyl methyltransferase (Icmt), an attractive and novel anticancer target. Herein, we report the synthesis of spermatinamine analogues
Total synthesis of the natural isoprenylcysteine carboxyl methyltransferase inhibitor spermatinamine
García, José,Pereira, Raquel,de Lera, Angel R.
, p. 5028 - 5030 (2009)
The first total synthesis of spermatinamine, an inhibitor of isoprenylcysteine carboxyl methyltransferase (Icmt) with a bromotyrosine-spermine-bromotyrosine dimeric structure is described.
Syntheses of pseudoceramines A-D and a new synthesis of spermatinamine, bromotyrosine natural products from marine sponges
Hillgren, J. Mikael,Oeberg, Christopher T.,Elofsson, Mikael
, p. 1246 - 1254 (2012/03/07)
Herein we report the total syntheses of pseudoceramine A-D (2-5) and spermatinamine (1) isolated from the marine sponge Pseudoceratina sp. Direct acyl substitution of α-hydroxyiminoesters with amine nucleophiles was developed as a key transformation. The synthetic compounds confirm the reported structures and importantly gives access to non-symmetrical spermine based natural products carrying two different bromotyrosine building blocks. Our new synthesis of spermatinamine is two steps shorter and more efficient than the previously reported sequence. The Royal Society of Chemistry 2012.
