1186468-22-3Relevant academic research and scientific papers
Bifunctional catalysis: Direct reductive amination of aliphatic ketones with an iridium-phosphate catalyst
Villa-Marcos, Barbara,Li, Chaoqun,Mulholland, Keith R.,Hogan, Philip J.,Xiao, Jianliang
experimental part, p. 2453 - 2472 (2010/07/15)
Chiral amines are one of the ubiquitous functional groups in fine chemical, pharmaceutical and agrochemical products, and the most convenient, economical, and ecobenign synthetic pathway to these amines is direct asymmetric reductive amination (DARA) of prochiral ketones. This paper shows that a wide range of aliphatic ketones can be directly aminated under hydrogenation conditions, affording chiral amines with good to excellent yields and with enantioselectivities up to 96% ee. The catalysis is effected by the cooperative action of a cationic Cp*Ir(III) complex and its phosphate counteranion. Copyright
Highly enantioselective synthesis of chiral secondary amines by gold(I)/ chiral bronsted acid catalyzed tandem intermodular hydroamination and transfer hydrogenation reactions
Liu, Xin-Yuan,Che, Chi-Ming
supporting information; experimental part, p. 4204 - 4207 (2009/12/31)
A method for the synthesis of enantiomerically enriched secondary amines with excellent ee values through the tandem intermolecular hydroamination/ transfer hydrogenation of alkynes using a "gold(I) complex-chiral Bronsted acid" protocol is developed. The
