1186485-80-2Relevant academic research and scientific papers
Large-scale synthesis of SB-462795, a cathepsin K inhibitor: the RCM-based approaches
Wang, Huan,Matsuhashi, Hayao,Doan, Brian D.,Goodman, Steven N.,Ouyang, Xi,Clark Jr., William M.
experimental part, p. 6291 - 6303 (2009/12/04)
Two stereoselective syntheses of SB-462795, a highly potent cathepsin K inhibitor, are described. Both routes feature a C5-C6 disconnection by ring closing metathesis to construct an azepane ring and are amenable to large-scale manufacturing.
