1186491-91-7Relevant articles and documents
Pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione derivatives as novel small molecule chaperone amplifiers
Zhou, Yuefen,Wei, Linyi,Brady, Thomas P.,Murali Mohan Redddy,Nguyen, Tram,Chen, Jinhua,Au, Qingyan,Yoon, Il Sang,Yip, Gary,Zhang, Bin,Barber, Jack R.,Ng, Shi Chung
experimental part, p. 4303 - 4307 (2010/05/18)
Pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione derivatives were investigated as novel small molecule amplifiers of heat shock factor 1 transcriptional activity. Lead optimization led to the discovery of compound 4A-13, which displayed potent HSF1 activit
