1186509-19-2

Usage

Uses

Used in Pharmaceutical Industry:
C₁₈H₂₇NO₂ is used as an inhibitor for the LasR receptor in P. aeruginosa, a type of bacteria, for the purpose of disrupting quorum sensing and potentially controlling bacterial infections.
Used in Research Applications:
C₁₈H₂₇NO₂ is used as a research tool to study the mechanisms of quorum sensing in P. aeruginosa and other bacteria that utilize similar signaling molecules. This can help in understanding bacterial communication and developing new strategies for combating bacterial infections.
Used in Drug Development:
C₁₈H₂₇NO₂ serves as a starting point for the development of new drugs targeting quorum sensing in bacteria, which could lead to novel therapeutic approaches for treating bacterial infections, especially those resistant to conventional antibiotics.

Upstream product

• 596104-60-8 (2-nonyl-[1,3]dioxolan-2-yl)-acetic acid 
• 62-53-3 aniline 
• 182359-65-5 5-decanoyl-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 112-13-0 n-decanoyl chloride 
• 2033-24-1 cycl-isopropylidene malonate 

Relevant academic research and scientific papers

Inhibition of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells by quorum sensing autoinducer-mimics

Pseudomonas aeruginosa is a notorious human pathogen associated with a range of life-threatening nosocomial infections. There is an increasing problem of antibiotic resistance in P. aeruginosa, highlighted by the emergence of multi-drug resistant strains.

Design, synthesis, and biological evaluation of abiotic, non-lactone modulators of LuxR-type quorum sensing

Quorum sensing (QS) is a cell-cell signaling mechanism that allows bacteria to monitor their population size and alter their behavior at high cell densities. Gram-negative bacteria use N-acylated L-homoserine lactones (AHLs) as their primary signals for QS. These signals are susceptible to lactone hydrolysis in biologically relevant media, and the ring-opened products are inactive QS signals. We have previously identified a range of non-native AHLs capable of strongly agonizing and antagonizing QS in Gram-negative bacteria. However, these abiotic AHLs are also prone to hydrolysis and inactivation and thereby have a relatively short time window for use (～12-48 h). Non-native QS modulators with reduced or no hydrolytic instability could have enhanced potencies and would be valuable as tools to study the mechanisms of QS in a range of environments (for example, on eukaryotic hosts). This study reports the design and synthesis of two libraries of new, non-hydrolyzable AHL mimics. The libraries were screened for QS modulatory activity using LasR, LuxR, and TraR bacterial reporter strains, and several new, abiotic agonists and antagonists of these receptors were identified.

Non-Lactone Carbocyclic and Heterocyclic Antagonists and Agonists of Bacterial Quorum Sensing

Compounds which modulate quorum sensing in quorum sensing bacteria. Compounds of the invention inhibit quorum sensing and/or activate quorum sensing in various bacteria. Compounds that inhibit quorum sensing are particularly useful for inhibition of detri