118653-18-2

Upstream product

• 118652-95-2 3-(2-methoxy-phenyl)-acryloyl azide 
• 118653-01-3 1-((E)-2-Isocyanato-vinyl)-2-methoxy-benzene 
• 1011-54-7 2-methoxycinnamic acid 
• 108-24-7 acetic anhydride 
• 118653-06-8 methyl(E)-N-2-(2-methoxyphenyl)ethenyl carbamate 

Downstream Products

• 118653-31-9 N-[(E)-2-(2-Methoxy-phenyl)-vinyl]-acetamide 

Relevant academic research and scientific papers

Synthesis of Enamides

(Z)-3-Arylprop-2-enoic acids can be converted by the Curtius procedure, through the acyl azides, into (Z)-2-arylethenyl isocyanates, which with methanol give methyl (Z)-N-(2-arylethenyl)carbamates.Acylation of the (Z)-enecarbamates, through their anions, leads to methyl (Z)-N-acyl-N-(2-arylethenyl)carbamates, which on treatment with lithium iodide in boiling N,N-dimethylformamide or acetonitrile undergo demethoxycarbonylation to give (Z)-enamides.The stereospecific route to enamides can also be used in the E-series.Treatment of (Z)- or (E)-2-arylethenyl isocyanates with trifluoroacetic acid gives (E)-N-(2-arylethenyl)trifluoroacetamides,the anions of which, with acylating agents, give (E)-enamides directly.