1186579-70-3

Upstream product

• 1700-37-4 3-Benzyloxybenzaldehyde 
• 7524-52-9 (S)-tryptophan methyl ester hydrochloride 
• 109-72-8 n-butyllithium 
• 32315-10-9 bis(trichloromethyl) carbonate 

Downstream Products

• 462630-41-7 (5R,11aS)-2-butyl-5-(3-hydroxyphenyl)-6H-1,2,3,5,11,11a-hexahydroimidazo[1,5-b]-β-carboline-1,3-dione 

Relevant academic research and scientific papers

Highly diastereoselective crystallization-induced asymmetric transformation of 1,3-disubstituted-tetrahydro-β-carbolines in water

A green and highly stereoselective method for the synthesis of cis or trans-1,3-disubstituted-tetrahydro-β-carbolines has been developed using water as the solvent. A mixture of cis and trans-1,3-disubstituted-tetrahydro-β-carboline hydrochlorides can be converted to a single cis or trans isomer via a crystallization-induced asymmetric transformation process. It is possible to get both isomers using this method by incorporating different additives in water. This method has advantages such as environmental friendliness, high stereoselectivity, suitability for industrialization, and non-toxicity.