1186609-65-3

Basic information

• Product Name: 5-AMino-3-Methoxy-1H-pyrazolo[3,4-b]pyridine
• Synonyms: 5-AMino-3-Methoxy-1H-pyrazolo[3,4-b]pyridine;3-Methoxy-1h-pyrazolo[3,4-b]pyridine-5-aMine;3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-amine
• CAS NO: 1186609-65-3
• Molecular Formula: C₇H₈N₄O
• Molecular Weight: 164.16462
• Mol File: 1186609-65-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 415.1±40.0 °C(Predicted)
• Appearance: /
• Density: 1.432±0.06 g/cm3(Predicted)
• PKA: 9.76±0.40(Predicted)
• CAS DataBase Reference: 5-AMino-3-Methoxy-1H-pyrazolo[3,4-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMino-3-Methoxy-1H-pyrazolo[3,4-b]pyridine(1186609-65-3)
• EPA Substance Registry System: 5-AMino-3-Methoxy-1H-pyrazolo[3,4-b]pyridine(1186609-65-3)

Safety Data

• Hazardous Substances Data: 1186609-65-3(Hazardous Substances Data)

Upstream product

• 1186614-21-0 3-methoxy-5-nitro-1H-pyrazolo[3,4-b]pyridine 

Downstream Products

• 1186607-05-5 Raf inhibitor a 
• 1186609-50-6 2,6-difluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-3-nitrobenzamide 
• 1186607-85-1 2-chloro-6-fluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-3-(propylsulfonamido)benzamide 
• 1186607-81-7 2,6-difluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-3-(N-propylsulfamoylamino)benzamide 
• 1186607-87-3 3-(N-ethyl-N-methylsulfamoylamino)-2,6-difluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)benzamide 
• 1268718-14-4 3-(benzyloxy)-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)benzamide 
• 1268718-53-1 6-chloro-2-fluoro-3-hydroxy-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)benzamide 
• 1186607-42-0 6-chloro-2-fluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-3-(propylsulfonamido)benzamide 
• 1186607-69-1 2,6-difluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-3-(phenylsulfonamido)benzamide 
• 1186609-51-7 3-amino-2,6-difluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)benzamide 
• 1186608-20-7 2,6-difluoro-3-(furan-2-sulfonamido)-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)benzamide 
• 1186608-24-1 C₁₈H₁₃F₂N₅O₄S₂ 
• 1186608-15-0 2,6-difluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-3-(1-methyl-1H-imidazole-4-sulfonamido)benzamide 
• 1186608-23-0 C₁₉H₁₄F₂N₆O₄S 

Relevant articles and documents

Synthesis of 2,6-difluoro-N-(3-[11C]methoxy-1H-pyrazolo[3,4-b] pyridine-5-yl)-3-(propylsulfonamidio)benzamide as a new potential PET agent for imaging of B-RafV600E in cancers

The authentic standard 2,6-difluoro-N-(3-methoxy-1H-pyrazolo[3,4-b] pyridine-5-yl)-3-(propylsulfonamidio)benzamide was synthesized from 2,6-difluorobenzoic acid and 3-amino-5-hydroxypyrazole in 9 steps with 1% overall chemical yield. Direct desmethylation

PYRAZOLE [3, 4-B] PYRIDINE RAF INHIBITORS

Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.