1186637-82-0

Basic information

• Product Name: 3-chloro-5-(hydroxymethyl)picolinonitrile
• Synonyms: 3-chloro-5-(hydroxymethyl)picolinonitrile
• CAS NO: 1186637-82-0
• Molecular Formula: C₇H₅ClN₂O
• Molecular Weight: 168.5804
• Mol File: 1186637-82-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 376.6±42.0 °C(Predicted)
• Appearance: /
• Density: 1.42±0.1 g/cm3(Predicted)
• PKA: 12.90±0.10(Predicted)
• CAS DataBase Reference: 3-chloro-5-(hydroxymethyl)picolinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-5-(hydroxymethyl)picolinonitrile(1186637-82-0)
• EPA Substance Registry System: 3-chloro-5-(hydroxymethyl)picolinonitrile(1186637-82-0)

Safety Data

• Hazardous Substances Data: 1186637-82-0(Hazardous Substances Data)

Upstream product

• 401566-69-6 ethyl 5,6-dichloronicotinate 
• 41667-95-2 5,6-dichloronicotinic acid 
• 557-21-1 zinc(II) cyanide 
• 54127-30-9 5,6-dichloro-3-pyridinemethanol 
• 1186637-81-9 3-chloro-5-((methoxymethoxy)methyl)picolinonitrile 

Downstream Products

• 1384262-81-0 3-chloro-5-phenoxymethyl-pyridine-2-carbonitrile 
• 1384262-42-3 7-(4-fluorophenyl)-3-phenoxymethyl-6,7-dihydro-5H-[1,7]-naphthyridin-8-one 
• 1616293-34-5 3-phenoxymethyl-7R-(1,2,2-trimethyl-propyl)-6,7-dihydro-5H-[1,7]naphthyridin-8-one 
• 1384262-63-8 7-methyl-3-(phenoxymethyl)-6,7-dihydro-1,7-naphthyridin-8(5H)-one 
• 1384262-62-7 3-phenoxymethyl-6,7-dihydro-5H-[1,7]naphthyridin-8-one 
• 1629240-47-6 C₂₂H₂₀N₂O₂ 
• 1384262-85-4 3-(2-oxo-ethyl)-5-phenoxymethyl-pyridine-2-carboxylic acid methyl ester 
• 1384262-84-3 3-allyl-5-phenoxymethyl-pyridine-2-carboxylic acid methyl ester 
• 1384262-83-2 3-chloro-5-phenoxymethyl-pyridine-2-carboxylic acid methyl ester 
• 1384262-82-1 3-chloro-5-phenoxymethyl-pyridine-2-carboxylic acid 

Relevant articles and documents

Homogenous suspension of immunopotentiating compounds and uses thereof

The present invention generally relates to homogeneous suspensions of small molecule immune potentiators (SMIPs) that are capable of stimulating or modulating an immune response in a subject in need thereof. The homogeneous suspensions may be used in combinations with various antigens or adjuvants for vaccine therapies.

Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu 5)

Positive allosteric modulators (PAMs) of metabotropic glutamate receptor 5 (mGlu5) represent a promising therapeutic strategy for the treatment of schizophrenia. Starting from an acetylene-based lead from high throughput screening, an evolved bicyclic dihydronaphthyridinone was identified. We describe further refinements leading to both dihydronaphthyridinone and tetrahydronaphthyridine mGlu5 PAMs containing an alkoxy-based linkage as an acetylene replacement. Exploration of several structural features including western pyridine ring isomers, positional amides, linker connectivity/position, and combinations thereof, reveal that these bicyclic modulators generally exhibit steep SAR and within specific subseries display a propensity for pharmacological mode switching at mGlu5 as well as antagonist activity at mGlu3. Structure-activity relationships within a dihydronaphthyridinone subseries uncovered 12c (VU0405372), a selective mGlu5 PAM with good in vitro potency, low glutamate fold-shift, acceptable DMPK properties, and in vivo efficacy in an amphetamine-based model of psychosis.

COMPOUNDS

Compounds of Formula (I) or pharmaceutically acceptable salts or N-oxides thereof: (relative chemistry shown) pharmaceutical compositions comprising them, their use in therapy especially against tuberculosis, and methods of preparing them are described.