1186642-40-9Relevant academic research and scientific papers
New Sterol Derivatives from the Marine Sponge Xestospongia sp.
Cheng, Zhongbin,Liu, Dong,de Voogd, Nicole J.,Proksch, Peter,Lin, Wenhan
, p. 588 - 596 (2016)
Chemical examination of a marine sponge Xestospongia sp. resulted in the isolation of 20 sterol derivatives (1 – 20), including eight new sterols namely aragusterols J – L (1 – 3), (5α,7α,12β,22E)-7,12,18-trihydroxystigmast-22-en-3-one (4), (5α,7α,12β,24R)- and (5α,7α,12β,24S)-7,12,20-trihydroxystigmastan-3-one (5/6), and (5α,7α,12β,22E,24R)- and (5α,7α,12β,22E,24S)-7,12,20-trihydroxyergost-22-en-3-one (7/8). The structures of new compounds were determined through extensive spectroscopic analyses and chemical conversion. The sterol diversity was mainly characterized by the presence of a cyclopropane unit at side chain, while compound 4 with 18-hydroxymethyl group was found in stigmasterol family for the first time. Cytotoxic test revealed the inhibitory effects of compounds 1, 4, and 17 against human leukemia cell line K562 with IC50values of 18.3, 24.1, and 34.3 μm, respectively.
