118665-03-5

Usage

Structure

Phenyl ring with a fluorine atom at the 2 position and a nitro group at the 6 position, attached to an ethyl alcohol group

Usage

Reagent or intermediate in organic synthesis and pharmaceutical research

Applications

Potential use in the development of new drugs and pharmaceutical products

Building block

Valuable for creating various organic molecules with specific properties and functions due to the presence of fluorine and nitro groups.

Upstream product

• 50-00-0 formaldehyd 
• 769-10-8 1-fluoro-2-methyl-3-nitrobenzene 

Downstream Products

• 179691-23-7 2-(2-fluoro-6-nitrophenyl)ethoxycarbonyl chloride 
• 290353-54-7 methanesulfonic acid 2-(2-fluoro-6-nitro-phenyl)-ethyl ester 
• 122455-46-3 2-(2-benzyloxyethyl)-3-fluoronitrobenzene 
• 122455-48-5 2-(2-Benzyloxyethyl)-3-fluorophenylhydrazine hydrochloride 
• 122455-47-4 2-(2-Benzyloxyethyl)-3-fluoroaniline hydrochloride 
• 122455-54-3 4-{[2-(2-Benzyloxy-ethyl)-3-fluoro-phenyl]-hydrazono}-butan-1-ol 
• 179691-38-4 5'-O-(2-(2-fluoro-6-nitrophenyl)ethoxycarbonyl)thymidine 
• 301645-41-0 1-fluoro-3-nitro-2-vinyl-benzene 

Relevant academic research and scientific papers

4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES

Compounds of formula (I) processes for their production and their use as pharmaceuticals.

A new method for the synthesis of 2,6-dinitro and 2-halo-6-nitrostyrenes

A new method for the synthesis of 2-halo-6-nitrostyrenes from 2-halo-6-nitrotoluenes is disclosed. Also described is a one-pot process for the synthesis of 2,6-dinitristyrene from 2,6-dinitrotoluene. (C) 2000 Elsevier Science Ltd.

New photolabile protecting groups in nucleoside and nucleotide chemistry - Synthesis, cleavage mechanisms and applications

New photolabile protecting groups have been found in the 2-(2- nitrophenyl)ethoxycarbonyl and the 2-(2-nitrophenyl)ethylsulfonyl group, respectively. The influence of substituents at the phenyl ring as well as the side-chain has been investigated regarding the photolysis rates on irradiation at 365 mn. β-Branching in the side-chain leads to highly increased rates of photodeprotection. A new type of photocleavage mechanism consisting of a photoinduced β-elimination process is proposed.

Nucleoside derivatives with photolabile protective groups

The invention relates to nucleoside derivatives having photolabile protective groups of the general formula (I) STR1 in which R1 =H, NO2, CN, OCH3, halogen or alkyl or alkoxyalkyl having 1 to 4 C atoms R2 =H, OCH3 R3 =H, F, Cl, Br, NO2 R4 =H, halogen, OCH3, or an alkyl radical having 1 to 4 C atoms R5 =H or a usual functional group for preparing oligonucleotides R6 =H, OH, halogen or XR8, where X=O or S and R8 represents a protective group usual in nucleotide chemistry, B=adenine, cytosine, guanine, thymine, uracil, 2,6-diaminopurin-9-yl, hypoxanthin-9-yl, 5-methylcytosin-1-yl, 5-amino-4-imidazolcarboxamid-1-yl, or 5-amino-4-imidazolcarboxamid-3-yl, where in the case of B=adenine, cytosine or guanine, the primary amino function optionally exhibits a permanent protective group. These derivatives may be used for the light-controlled synthesis of oligonucleotides on a DNA chip.

Synthetic Entries to 6-Fluoro-7-substituted Indole Derivatives

Three practical synthetic entries of functionalized 6-fluoro-7-substituted indole derivatives were developed in connection with the preparation of 7-fluoro-8-substituted-1,3,4,9-tetrahydropyranoindole-1-acetic acid derivatives 11.The first route, w

Production of substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids

Process for the production of substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid having useful analgesic and anti-inflammatory activity.