118666-26-5

Upstream product

• 867348-85-4 ethyl 2-(2,4-dichlorophenyl)-3-hydroxyprop-2-enoate 

Downstream Products

• 1629188-83-5 (2Z,4E)-ethyl 5-(4-chlorophenyl)-2-(2,4-dichlorophenyl)penta-2,4-dienoate 
• 25173-21-1 2-(2,4-dichlorophenyl)propanoic acid 

Relevant academic research and scientific papers

Concise Synthesis of 2-Arylpropanoic Acids and Study of Unprecedented Reduction of 3-Hydroxy-2-arylpropenoic Acid Ethyl Ester to 2-Arylpropenoic Acid Ethyl Ester by BH3·THF

We have developed a concise method of synthesizing racemic arylpropanoic acids, which have been widely used as nonsteroidal anti-inflammatory drugs (NSAIDs). The synthesis involves only four steps from commercially available benzaldehyde. The synthesis incorporates an unprecedented reduction reaction, conversion of 3-hydroxy-2-arylpropenoic acid ethyl ester to 2-arylpropenoic acid ethyl ester by BH3·THF. The reduction reaction has been investigated and optimized.

2,4,4-tri- and 2,2,4,4-tetra substituted-1,3-dioxolane antifungal, antiallergy compounds

Novel 1,3-dioxolane compounds useful as antifungal and antiallergy agents and represented by the formula STR1 wherein Ar is thienyl, pyridyl, biphenyl, phenyl or phenyl substituted by one or more of halo, nitro, cyano, lower alkyl, lower alkoxy or perhalo