1186722-01-9Relevant academic research and scientific papers
Enamides and enesulfonamides as nucleophiles: Formation of complex ring systems through a platinum(II)-catalyzed addition/Friedel-Crafts pathway
Kozak, Jennifer A.,Dodd, Jennifer M.,Harrison, Tyler J.,Jardine, Katherine J.,Patrick, Brian O.,Dake, Gregory R.
supporting information; experimental part, p. 6929 - 6935 (2009/12/06)
(Chemical Equation Presented) Cyclic enamine derivatives (enesulfonamides and enamides) tethered to an 1-arylalkynyl fragment undergo a platinum(II)-catalyzed tandem alkyne addition/Friedel-Crafts ring closure to formnitrogen-containing polycyclic structures.Regioselectivity in the initial addition of the enesulfonamide or enamide nucleophile to the platinum(II)-alkyne complex is important. Electron-rich arenes and heterocycles led to the formation of products resulting from an initial 6-endo cyclization. Twenty-three examples of this process are presented.
