118679-71-3

Upstream product

• 108352-97-2 5-((4-methoxybenzyl)oxy)-4-oxo-4H-pyran-2-carboxylic acid 
• 118708-61-5 5-p-methoxybenzyloxy-2-hydroxymethyl-4-pyrone 
• 501-30-4 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 118708-42-2 Diphenylmethyl (6R,7R)-3-[4,5-Di(4-methoxybenzyloxy)pyridin-2-yl]carbonyloxymethyl-7-[(R)-2-(4-ethyl-2,3-dioxopiperazin-1-yl)carbonylamino-2-phenylacetamido]-7-formamidoceph-3-em-4-carboxylate 

Relevant academic research and scientific papers

NOVEL CEPHALOSPORIN DERIVATIVE AND PHARMACEUTICAL COMPOSITION THEREOF

The present invention relates to novel cephalosporin derivatives represented by Chemical Formula 1. Wherein, X, Y, L, R1, and R2 are as same as defined in the description of the invention. The present invention also relates to pharmaceutical antibiotic compositions comprising a novel celphalosporin derivative represented by Chemical Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient. According to the present invention, novel cephalosporin derivatives, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient for the broad spectrum of antibiotic resistant, low toxicity, particularly in Gram-negative bacteria, which can be useful with strong antimicrobial activity.

NOVEL CEPHALOSPORIN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF

The present invention relates to novel cephalosporin derivatives represented by Chemical Formula 1. Wherein, X, Y, L, R1, and R2 are as same as defined in the description of the invention. The present invention also relates to pharmaceutical antibiotic compositions comprising a novel celphalosporin derivative represented by Chemical Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient. According to the present invention, novel cephalosporin derivatives, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient for the broad spectrum of antibiotic resistant, low toxicity, particularly in Gram-negative bacteria, which can be useful with strong antimicrobial activity.

Cephalosporins, processes for their preparation and pharmaceutical compositions containing them

Antibacterial agents have the formula (Ia) or are pharmaceutically acceptable salts or invivohydrolysable esters thereof: wherein R1 is an acyl group, in particular that of an antibacterially active cephalosporin; R2 is hydrogen, methoxy, or formamido; Y is S, SO, SO2, O or CH2; X is oxygen, sulphur, or -NH- and R4 is a group of the formula CO Z R5 wherein Z is -CH=CH-, -(CH2)n- or -NH-; n is 0, 1 or 2; and R5 is: wherein R6 and R7 are the same or different, each representing hydroxy or protected hydroxy and R8 is hydroxy, amino, halogen or carboxy. The use of the compounds of formula (Ia) and intermediates for their preparation are also disclosed.

Cephalosporins, process for their preparation, pharmaceutical compositions containing them and intermediates

β-Lactam antibiotics are disclosed which have the formula (IA) or are pharmaceutically acceptable salts or pharmaceutically acceptable invivohydrolysable esters thereof: wherein Y is a 1-(optionally substituted amino)-1H-tetrazol-5-yl, 4-(optionally subst