118679-75-7Relevant academic research and scientific papers
Synthesis and structure-activity relationships of cephalosporins with C-3' catechol-containing residues
Arnould,Bertrandie,Bird,Boucherot,Jung,Lohmann,Olivier,Bailey,Bell,Davies
, p. 2631 - 2642 (2007/10/02)
Cephalosporins with new catechol substituents at C-3' have been synthesized, including novel compounds with C-3' carbon-carbon bonds. Many of these compounds have high potency against Gram-negative bacteria, in particular against resistant strains like Ps
Cephalosporins, processes for their preparation and pharmaceutical compositions containing them
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, (2008/06/13)
Antibacterial agents have the formula (Ia) or are pharmaceutically acceptable salts or invivohydrolysable esters thereof: wherein R1 is an acyl group, in particular that of an antibacterially active cephalosporin; R2 is hydrogen, methoxy, or formamido; Y is S, SO, SO2, O or CH2; X is oxygen, sulphur, or -NH- and R4 is a group of the formula CO Z R5 wherein Z is -CH=CH-, -(CH2)n- or -NH-; n is 0, 1 or 2; and R5 is: wherein R6 and R7 are the same or different, each representing hydroxy or protected hydroxy and R8 is hydroxy, amino, halogen or carboxy. The use of the compounds of formula (Ia) and intermediates for their preparation are also disclosed.
