1187055-81-7 Usage
Description
3-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-cyclohex-2-enone is an organic compound characterized by its unique chemical structure, which features a cyclohexenone core with a tetramethyl-1,3,2-dioxaborolan-2-yl group attached to the 3-position. 3-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-cyclohex-2-enone is known for its potential applications in the synthesis of various pharmaceuticals and chemical products.
Uses
Used in Pharmaceutical Industry:
3-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-cyclohex-2-enone is used as an intermediate in the synthesis of β-secretase inhibitors for the treatment of Alzheimer's disease. These inhibitors target the enzyme β-secretase, which plays a crucial role in the production of amyloid-beta peptides, a key factor in the development of Alzheimer's disease. By inhibiting this enzyme, the compound can potentially slow down or prevent the progression of the disease.
Used in Chemical Synthesis:
3-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-cyclohex-2-enone can also be utilized as a building block in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique structure allows for further functionalization and modification, making it a versatile starting material for the development of new molecules with diverse applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1187055-81-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,7,0,5 and 5 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1187055-81:
(9*1)+(8*1)+(7*8)+(6*7)+(5*0)+(4*5)+(3*5)+(2*8)+(1*1)=167
167 % 10 = 7
So 1187055-81-7 is a valid CAS Registry Number.
1187055-81-7Relevant articles and documents
Compounds used as JAK inhibitor, and use of compounds
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Paragraph 0431; 0432; 0433; 0434; 0435, (2017/08/27)
The invention provides compounds used as a JAK inhibitor, and a use of the compounds, and concretely provides compounds (represented by formula (I)) with JAK inhibition activity or a stereoisomer, a geometric isomer, a tautomer, a racemate, a nitrogen oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, and a medicinal composition including the compounds. The invention also discloses a use of the compounds or the medicinal composition thereof in the preparation of medicines used for treating autoimmune diseases or proliferative diseases.
N-B dative bond-induced [3.3.0] bicyclic boronate-tethered exo-selective intramolecular Diels-Alder reaction
Feng, Chao,Wang, Hong,Xu, Liang,Li, Pengfei
supporting information, p. 7136 - 7139 (2015/07/01)
We report herein a highly exo-selective intramolecular Diels-Alder reaction of alkenyl boronates which employs an N-B dative bond-involved bicyclic rigid tether. Complex C(sp3)-rich polycyclic molecules containing up to 8 stereocenters can be readily formed via an operationally simple two-step procedure.
BICYCLIC AROMATIC CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS
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Paragraph 0555; 0556, (2014/07/23)
The present disclosure describes bicyclic aromatic carboxamide derivatives, as well as their compositions and methods of use. The compounds inhibit the activity of the Pim kinases, and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.
