1187182-27-9Relevant academic research and scientific papers
First asymmetric synthesis of (Un)saturated 1-Alkylbenzo[c]azepin-3-ones: Extension to the corresponding benzazeplnes
Dumoulin, David,Lebrun, Stepfaane,Deniau, Eric,Couture, Axel,Grandclaudon, Pierre
experimental part, p. 3741 - 3752 (2009/12/05)
A flexible route for the stereoselective synthesis of a variety of structurally diverse (1R)-1-alkyldihydro and tetrahydro-benzazepin(ones) has been developed. The key step is a highly diastereoselective 1,2-addition process applied to a stereopure aromatic hydrazone combined with a ring-closing metathesis reaction to secure the formation of the seven-membered azaheterocycle ring system.
