118719-00-9

Upstream product

• 582-33-2 3-aminobenzoic acid ethyl ester 
• 618-98-4 ethyl 3-nitrobenzoate 

Downstream Products

• 30130-49-5 3,3'-azoxy-di-benzoic acid diethyl ester 

Relevant academic research and scientific papers

Synthesis and Binding Studies of a Tetra-α Aryl-Extended Photoresponsive Calix[4]pyrrole Receptor Bearing meso-Alkyl Substituents

We report the synthesis of the tetra-α isomer of a meso-azobenzene-extended calix[4]pyrrole receptor bearing alkyl substituents at its lower rim. In solution, the photo-irradiation of the all-trans receptor induces the isomerization of its azobenzene units producing at the photostationary state a mixture of cis-enriched counterparts in which the all-cis receptor is the major component (85 %). Simple molecular modelling studies show that the cone conformation of the all-trans isomer possesses a deep aromatic cavity open at one end. Otherwise, the isomers containing cis-azobenzene groups display a significant reduction of the cavity size and a diminution of the number of CH–π and π–π interactions that can be established with the included guest. The interaction of the all-trans isomer, as well as of the mixture mainly containing the all-cis receptor, with electron-rich molecular guests (neutral and anionic) was probed, in dichloromethane and acetonitrile solutions, using 1H NMR spectroscopic titrations. Isothermal titration calorimetry (ITC) experiments enabled the accurate determination of the binding constants of the inclusion complexes.

Rhodium(III)-catalyzed regioselective C–H nitrosation/annulation of unsymmetrical azobenzenes to synthesize benzotriazole N-oxides via a RhIII/RhIII redox-neutral pathway

A Rh(III)-catalyzed regioselective C–H nitrosation/annulation reaction of unsymmetrical azobenzenes with [NO][BF4] has been developed to achieve high-yielding syntheses of benzotriazole N-oxides with excellent functional group tolerance. Computational studies have revealed that this oxidative C–H functionalization reaction involves an interesting redox-neutral Rh(III)/Rh(III) pathway without the change of Rh oxidation state.

Azo aryl urea derivative, and preparation method and application thereof

The invention relates to an azo aryl urea derivative, and a preparation and an application thereof, and concretely discloses a compound represented by formula (I), or an optical isomer, a cis-trans-isomer or a pharmaceutically acceptable salt thereof, and a preparation method thereof. Definitions of substituent groups in the general formula are described in the specification and claims. The invention further discloses a composition containing the above compound, and an application thereof. The compound has excellent anticancer activity on HepG2 liver cancer cells, MGC803 gastric cancer cells,HCT116 colon cancer and the like.