1187193-66-3Relevant academic research and scientific papers
Highly selective iridium-catalyzed asymmetric hydrogenation of trifluoromethyl olefins: A new route to trifluoromethyl-bearing stereocenters
Engman, Mattias,Cheruku, Pradeep,Tolstoy, Paeivi,Bergquist, Jonas,Voelker, Sebastian F.,Andersson, Pher G.
supporting information; experimental part, p. 375 - 378 (2009/11/30)
Fluorine-containing compounds are useful in many applications ranging from pharmaceuticals to ferroelectric crystals. We have developed a new, highly enantioselective synthetic route to trifluoromethyl-bearing stereocenters in up to 96% ee via asymmetric hydrogenation using N,P-ligated iridium catalysts. We also hydrogenated an isomeric mixture of olefins; this reaction gave the hydrogenation product highly enantioselectively (87% ee), and only the E isomer was present after the reaction had reached 56% conversion.
