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1187209-20-6

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1187209-20-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1187209-20-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,7,2,0 and 9 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1187209-20:
(9*1)+(8*1)+(7*8)+(6*7)+(5*2)+(4*0)+(3*9)+(2*2)+(1*0)=156
156 % 10 = 6
So 1187209-20-6 is a valid CAS Registry Number.

1187209-20-6Downstream Products

1187209-20-6Relevant articles and documents

Discovering novel 7-azaindole-based series as potent AXL kinase inhibitors

Feneyrolles, Clémence,Guiet, Léa,Singer, Mathilde,Van Hijfte, Nathalie,Daydé-Cazals, Bénédicte,Fauvel, Bénédicte,Chevé, Gwéna?l,Yasri, Abdelaziz

, p. 862 - 866 (2017)

AXL is a receptor tyrosine kinase that plays a key role in tumor growth and proliferation. The scientific community has validated AXL as therapeutic target in the treatment of cancers for several years now, and several AXL inhibitors have been developed but none of them are approved. In this context, we started to design new kinase inhibitors targeting AXL from the 7-azaindole scaffold well known to interact with the ATP binding site of the kinase. Focused screening and chemical diversification around 7-azaindole scaffold were developed, based on modeling studies and medicinal chemistry rational, leading to the discovery of a new family of hits with potent inhibitory activity against AXL.

1H-PYRROLO[2,3-B]PYRIDINES

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Page/Page column 35, (2008/06/13)

Derivatives of pyrrolo[2,3-b]pyridine which are useful as SGK-1 kinase inhibitors are described herein. The invention described herein also describes pharmaceutical compositions containing derivatives of pyrrolo[2,3-b]pyridine and methods of using pyrrolo[2,3-b]pyridine derivatives and pharmaceutical compositions thereof in the treatment of diseases mediated by SGK-1.

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