1187303-53-2Relevant academic research and scientific papers
From lead to preclinical candidate: Optimization of β-homophenylalanine based inhibitors of dipeptidyl peptidase IV
Nordhoff, Sonja,Lopez-Canet, Meritxell,Hoffmann-Enger, Barbara,Bulat, Stephan,Cerezo-Galvez, Silvia,Hill, Oliver,Rosenbaum, Claudia,Rummey, Christian,Thiemann, Meinolf,Matassa, Victor G.,Edwards, Paul J.,Feurer, Achim
, p. 4818 - 4823 (2009)
A series of highly potent and selective inhibitors of DPP-4 was optimized for ADMET properties. The effort resulted in the discovery of inhibitor 1g, that exhibits excellent efficacy in an oral glucose tolerance test and an attractive pharmacokinetic prof
