1187312-98-6Relevant articles and documents
Synthesis and structure-activity relationships of novel benzofuran farnesyltransferase inhibitors
Asoh, Kohsuke,Kohchi, Masami,Hyoudoh, Ikumi,Ohtsuka, Tatsuo,Masubuchi, Miyako,Kawasaki, Kenichi,Ebiike, Hirosato,Shiratori, Yasuhiko,Fukami, Takaaki A.,Kondoh, Osamu,Tsukaguchi, Toshiyuki,Ishii, Nobuya,Aoki, Yuko,Shimma, Nobuo,Sakaitani, Masahiro
scheme or table, p. 1753 - 1757 (2009/12/07)
A series of benzofuran-based farnesyltransferase inhibitors have been designed and synthesized as antitumor agents. Among them, 11f showed the most potent enzyme inhibitory activity (IC50 = 1.1 nM) and antitumor activity in human cancer xenogra
