1187449-15-5

Basic information

• Product Name: 1H-Pyrrolo[2,3-b]pyridine, 2-cyclopropyl-5-fluoro-
• Synonyms: 1H-Pyrrolo[2,3-b]pyridine, 2-cyclopropyl-5-fluoro-;2-cyclopropyl-5-fluoro-1H-pyrrolo[2,3-b]pyridine
• CAS NO: 1187449-15-5
• Molecular Formula: C₁₀H₉FN₂
• Molecular Weight: 176.1902632
• Mol File: 1187449-15-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridine, 2-cyclopropyl-5-fluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridine, 2-cyclopropyl-5-fluoro-(1187449-15-5)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridine, 2-cyclopropyl-5-fluoro-(1187449-15-5)

Safety Data

• Hazardous Substances Data: 1187449-15-5(Hazardous Substances Data)

Usage

Heterocyclic compound

A compound that contains a ring structure with at least one nitrogen or other non-carbon atom In this case, the compound contains a pyrrolopyridine ring system.

Pyrrolopyridine ring system

A ring structure consisting of a pyrrole and a pyridine ring fused together This is the core structure of the compound.

Cyclopropyl substituent

A three-carbon ring with one double bond This is one of the two substituents attached to the pyrrolopyridine ring system.

Fluoro substituent

A fluorine atom This is the other substituent attached to the pyrrolopyridine ring system.

Potent inhibitor of protein kinase enzyme

The compound has been shown to be a strong inhibitor of the protein kinase enzyme, which plays a key role in cell growth and division.

Anti-cancer potential

The compound has been studied for its potential use as an anti-cancer agent due to its ability to inhibit cell proliferation.

Antimicrobial properties

The compound has been investigated for its activity against certain bacteria and fungi, showing promising results.

Upstream product

• 21717-96-4 2-amino-5-fluoropyridine 
• 869557-43-7 3-bromo-5-fluoropyridin-2-amine 
• 6746-94-7 Cyclopropylacetylene 
• 823218-51-5 5-fluoro-3-iodo-pyridin-2-amine 
• 1187449-13-3 3-(cyclopropylethynyl)-5-fluoro-2-pyridinamine 

Downstream Products

• 1187449-21-3 4-bromo-2-cyclopropyl-5-fluoro-1H-pyrrolo[2,3-b]pyridine 
• 1187448-62-9 4-(2-cyclopropyl-5-fluoro-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(2-hydroxyethyl)benzenesulfonamide 
• 1187448-58-3 4-(2-cyclopropyl-5-fluoro-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)benzenesulfonamide 

Relevant articles and documents

Novel 2-Substituted 7-Azaindole and 7-Azaindazole Analogues as Potential Antiviral Agents for the Treatment of Influenza

JNJ-63623872 (2) is a first-in-class, orally bioavailable compound that offers significant potential for the treatment of pandemic and seasonal influenza. Early lead optimization efforts in our 7-azaindole series focused on 1,3-diaminocyclohexyl amide and urea substitutions on the pyrimidine-7-azaindole motif. In this work, we explored two strategies to eliminate observed aldehyde oxidase (AO)-mediated metabolism at the 2-position of these 7-azaindole analogues. Substitution at the 2-position of the azaindole ring generated somewhat less potent analogues, but reduced AO-mediated metabolism. Incorporation of a ring nitrogen generated 7-azaindazole analogues that were equipotent to the parent 2-H-7-azaindole, but surprisingly, did not appear to improve AO-mediated metabolism. Overall, we identified multiple 2-substituted 7-azaindole analogues with enhanced AO stability and we present data for one such compound (12) that demonstrate a favorable oral pharmacokinetic profile in rodents. These analogues have the potential to be further developed as anti-influenza agents for the treatment of influenza.