1187472-34-9

Basic information

• Product Name: 6-chloro-4-((4-methoxyphenyl)ethynyl)-2H-chromen-2-one
• Synonyms: 6-chloro-4-((4-methoxyphenyl)ethynyl)-2H-chromen-2-one
• CAS NO: 1187472-34-9
• Molecular Weight: 310.737
• Mol File: 1187472-34-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6-chloro-4-((4-methoxyphenyl)ethynyl)-2H-chromen-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-4-((4-methoxyphenyl)ethynyl)-2H-chromen-2-one(1187472-34-9)
• EPA Substance Registry System: 6-chloro-4-((4-methoxyphenyl)ethynyl)-2H-chromen-2-one(1187472-34-9)

Safety Data

• Hazardous Substances Data: 1187472-34-9(Hazardous Substances Data)

Upstream product

• 635-93-8 5-chlorosalicyclaldehyde 
• 768-60-5 4-methoxyphenylacetylen 
• 19484-57-2 6-chloro-4-hydroxycoumarin 

Relevant articles and documents

Rapid Access of Alkynyl and Alkenyl Coumarins via a Dipyridinium Methylide and Propargylamine Cascade Reaction

A DMAP-catalyzed cascade approach allowing facile assembly of alkynyl coumarins is reported. By virtue of reactive o-AQM (in situ generated from modular propargylamine) and a new synthetic equivalent of acyl carbene (from pyridinium ylide), the reaction proceeds smoothly to afford a variety of alkynyl coumarins in good-to-excellent yields. This transition-metal-free and oxidant-free process features moderate functional group tolerance, particularly the-Br group; thus, this protocol circumvents the inherent shortcomings of the existing Sonogashira coupling of coumarin triflates. This versatile method is also found to be applicable to the preparation of β-alkenyl coumarins, resembling the outcomes of the current Heck-type coupling reaction.