1187488-10-3

Basic information

• Product Name: N,N'-bis[2-(4-hydroxyphenyl)ethyl]-1,4,5,8-naphthalenetetracarboxylic acid diimide
• Synonyms: N,N'-bis[2-(4-hydroxyphenyl)ethyl]-1,4,5,8-naphthalenetetracarboxylic acid diimide
• CAS NO: 1187488-10-3
• Molecular Weight: 506.514
• Mol File: 1187488-10-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N,N'-bis[2-(4-hydroxyphenyl)ethyl]-1,4,5,8-naphthalenetetracarboxylic acid diimide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-bis[2-(4-hydroxyphenyl)ethyl]-1,4,5,8-naphthalenetetracarboxylic acid diimide(1187488-10-3)
• EPA Substance Registry System: N,N'-bis[2-(4-hydroxyphenyl)ethyl]-1,4,5,8-naphthalenetetracarboxylic acid diimide(1187488-10-3)

Safety Data

• Hazardous Substances Data: 1187488-10-3(Hazardous Substances Data)

Upstream product

• 51-67-2 tyrosamine 
• 81-30-1 1,4,5,8-naphthalenetetracarboxylic dianhydride 

Relevant articles and documents

Quinone methides tethered to naphthalene diimides as selective G-quadruplex alkylating agents

We have developed novel G-quadruplex (G-4) ligand/alkylating hybrid structures, tethering the naphthalene diimide moiety to quaternary ammonium salts of Mannich bases, as quinone-methide precursors, activatable by mild thermal digestion (40°C). The bis-substituted naphthalene diimides were efficiently synthesized, and their reactivity as activatable bis-alkylating agents was investigated in the presence of thiols and amines in aqueous buffered solutions. The electrophilic intermediate, quinonemethide, involved in the alkylation process was trapped, in the presence of ethyl vinyl ether, in a hetero Diels-Alder [4 + 2] cycloaddition reaction, yielding a substituted 2-ethoxychroman. The DNA recognition and alkylation properties of these new derivatives were investigated by gel electrophoresis, circular dichroism, and enzymatic assays. The alkylation process occurred preferentially on the G-4 structure in comparison to other DNA conformations. By dissecting reversible recognition and alkylation events, we found that the reversible process is a prerequisite to DNA alkylation, which in turn reinforces the G-quadruplex structural rearrangement.