1187568-63-3Relevant academic research and scientific papers
Synthesis and optimization of 2-pyridin-3-yl-benzo[d][1,3]oxazin-4-one based inhibitors of human neutrophil elastase
Shreder, Kevin R.,Cajica, Julia,Du, Lingling,Fraser, Allister,Hu, Yi,Kohno, Yasushi,Lin, Emme C.K.,Liu, Steve J.,Okerberg, Eric,Pham, Lan,Wu, Jiangyue,Kozarich, John W.
, p. 4743 - 4746 (2009)
The hit-to-lead optimization of the HNE inhibitor 5-methyl-2-(2-phenoxy-pyridin-3-yl)-benzo[d][1,3]oxazin-4-one is described. A structure-activity relationship study that focused on the 5 and 7 benzoxazinone positions yielded the optimized 5-ethyl-7-metho
