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118758-47-7

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118758-47-7 Usage

Description

(2R,3R)-3-Methylpyrrolidine-2-carboxylic acid is a chemical compound with the molecular formula C7H13NO2. It is a derivative of pyrrolidine, a five-membered heterocyclic ring containing one nitrogen atom. (2R,3R)-3-Methylpyrrolidine-2-carboxylic acid exists as a colorless liquid and is characterized by its specific (2R,3R) stereochemistry, which refers to the orientation of the substituent groups around the asymmetric carbon atoms. This feature is crucial for its applications and reactivity in chemical processes.

Uses

Used in Pharmaceutical Industry:
(2R,3R)-3-Methylpyrrolidine-2-carboxylic acid serves as an important building block in the synthesis of various pharmaceuticals. Its unique stereochemistry and structural properties make it a valuable component in the development of new drugs, contributing to the creation of molecules with specific therapeutic effects and improved pharmacological properties.
Used in Agrochemical Industry:
In the agrochemical sector, (2R,3R)-3-Methylpyrrolidine-2-carboxylic acid is utilized in the synthesis of compounds that have applications in agriculture, such as pesticides and herbicides. Its role in these syntheses can lead to the development of more effective and targeted agrochemicals that can enhance crop protection and yield.
Used in Organic Synthesis:
(2R,3R)-3-Methylpyrrolidine-2-carboxylic acid is also used as a versatile building block for the production of a wide range of organic compounds. Its ability to participate in various chemical reactions makes it a useful intermediate in the synthesis of specialty chemicals, fragrances, and other fine chemicals that have applications across different industries.

Check Digit Verification of cas no

The CAS Registry Mumber 118758-47-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,8,7,5 and 8 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 118758-47:
(8*1)+(7*1)+(6*8)+(5*7)+(4*5)+(3*8)+(2*4)+(1*7)=157
157 % 10 = 7
So 118758-47-7 is a valid CAS Registry Number.

118758-47-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (3R)-3-Methyl-D-proline

1.2 Other means of identification

Product number -
Other names trans-3-Methyl-D-prolin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:118758-47-7 SDS

118758-47-7Downstream Products

118758-47-7Relevant articles and documents

Organocatalytic michael addition of nitro esters to a,β-unsaturated aldehydes: Towards the enantioselective synthesis of trans-3-substituted proline derivatives

Han, Man-Yi,Zhang, Yong,Wang, Huai-Zhen,An, Wan-Kai,Ma, Bao-Chun,Zhang, Yuan,Wang, Wei

, p. 2635 - 2640 (2013/01/15)

A facile five-step strategy has been developed for the enantioselective synthesis of trans-3- substituted proline derivatives with high diasteroselectivity (dr>20:1) and enantioselectivity (up to 97% ee). The key step is the asymmetric organocatalytic Michael addition of nitro esters to a,β-unsaturated aldehydes, which affords the chiral Michael adducts in high yields (up to 96%) and excellent enantioselectivity (up to 99% ee) by using diaryl- ACHTUNGTRENUNGprolinol silyl ether as the organocatalyst.

Highly Diasteroselective Michael-Addition of Lithiated Camphor Imines of Glycine Esters to α,β-Unsaturated Esters. Synthesis of Optically Pure 5-Oxo-2,4-pyrrolidinedicarboxylates of Unnatural Stereochemistry

Kanemasa, Shuji,Tatsukawa, Akira,Wada, Eiji

, p. 2875 - 2883 (2007/10/02)

The lithium enolates of camphor imines of glycine esters underwent highly diastereoselective Michael additions to the α,β-unsaturated esters.The tightly chelated structure of the Z,E enolates and the selective approach of the α,β-unsaturated esters to the

Synthesis of Enantio- and Diastereoiso-merically Pure Substituted Prolines via Condensation of Glycine with Olefins Activated by a Carbonyl Group

Belokon', Yuri N.,Bulychev, Aleksandr G.,Pavlov, Viacheslav A.,Fedorova, Eugenia B.,Tsyryapkin, Vladimir A.,et al.

, p. 2075 - 2084 (2007/10/02)

The glycine fragment in the nickel(II) complex (1) formed from the Schiff's base of glycine and (S)-o-benzophenone (2) undergoes base-catalysed Michael addition to acrylaldehyde, α-methylacrylaldehyde, (E)-crotonaldehyde, (E)-cinnamaldehyde, and methyl vinyl ketone.No products of 1,2-addition were found in the Et3N-catalysed reactions.Addition followed by epimerization of the isomeric complexes proceeds with high diastereoselectivity at Cα (90percent) and Cβ of the corresponding amino acid side chains.After chromatographic separation, the diastereoisomerically pure complexes were decomposed and the resulting dihydropyrrole-2-carboxylic acids reduced with NaBH3CN to give (S)-proline, trans-3-methyl-(S)-proline, trans-5-phenyl-(S)-proline, and a mixture of cis- and trans-5-methyl-(S)-prolines.The chiral auxiliary (2) was recovered in 80-90percent yield.

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