1187590-16-4Relevant articles and documents
Functionalized 3-amino-imidazo[1,2-a]pyridines: A novel class of drug-like Mycobacterium tuberculosis glutamine synthetase inhibitors
Odell, Luke R.,Nilsson, Mikael T.,Gising, Johan,Lagerlund, Olof,Muthas, Daniel,Nordqvist, Anneli,Karlen, Anders,Larhed, Mats
experimental part, p. 4790 - 4793 (2010/04/26)
3-Amino-imidazo[1,2-a]pyridines have been identified as a novel class of Mycobacterium tuberculosis glutamine synthetase inhibitors. Moreover, these compounds represent the first drug-like inhibitors of this enzyme. A series of compounds exploring structural diversity in the pyridine and phenyl rings have been synthesized and biologically evaluated. Compound 4n was found to be the most potent inhibitor (IC50 = 0.38 ± 0.02 μM). This compound was significantly more potent than the known inhibitors, l-methionine-SR-sulfoximine and phosphinothricin.
