1187734-41-3Relevant academic research and scientific papers
C5-Modified nucleosides exhibiting anticancer activity
Lee, Yoon-Suk,Park, Sun Min,Kim, Hwan Mook,Park, Song-Kyu,Lee, Kiho,Lee, Chang Woo,Kim, Byeang Hyean
scheme or table, p. 4688 - 4691 (2010/04/28)
We describe (i) a simple method for the synthesis of C5-modified nucleosides from 5-iodo-2′-deoxyuridine and (ii) their activity against six types of human cancer cell lines (HCT15, MM231, NCI-H23, NUGC-3, PC-3, ACHN). We generated nitrile oxides in situ from oximes using a commercial bleaching agent; their cycloadditions with 5-ethynyl-2′-deoxyuridine yielded isoxazole derivatives possessing activity against the cancer cell lines. We synthesized several azides from benzylic bromides and their click reactions with 5-ethynyl-2′-deoxyuridine provided triazole derivatives.
