1187772-47-9

Upstream product

• 1006-68-4 5-phenyloxazole 
• 111409-79-1 1-bromo-2-(triisopropylsilyl)acetylene 
• 89343-06-6 tris-iso-propylsilyl acetylene 

Relevant academic research and scientific papers

Nickel- and copper-catalyzed direct alkynylation of azoles and polyfluoroarenes with terminal alkynes under O2 or atmospheric conditions

The direct C-H alkynylation of azoles with terminal alkynes proceeds efficiently under a nickel/O2 catalytic system. On the other hand, a copper/air catalyst enables the coupling of polyfluoroarenes with terminal alkynes. These catalyses provide new accesses to arylacetylenes through the formal direct Sonogashira coupling.

Highly efficient and versatile pd-catalyzed direct alkynylation of both azoles and azolines

A highly efficient and versatile Pd-catalyzed direct alkynylation reaction of heterocycles with 1-bromoalkynes was developed. The substrate scope of the reaction was very broad to include not only azoles but also azolines for the first time, thus offering an important advance in the direct functionalization of heterocycles.

Copper as a powerful catalyst in the direct alkynylation of azoles

[Chemical equation presented] Copper-bottomed catalysis! The direct alkynylation of azoles through a copper-based C - H bond activation, using alkynylbromides as the coupling partner, has been developed (see scheme). The method is very rapid, is functional-group tolerant, and provides a straightforward entry to diverse alkynyl heterocycles that is complementry to the Sonogashira reaction.

Nickel-catalyzed direct alkynylation of azoles with alkynyl bromides

The direct C - H alkynylation of azoles with alkynyl bromides proceeds efficiently In the presence of a nickel-based catalyst system. The reaction enables the introduction of various alkynyl groups bearing aryl, alkenyl, alkyl, and silyl substituents to t