1187921-84-1

Basic information

• Product Name: 1-(2-iodoethoxy)-2-methoxybenzene
• Synonyms: 1-(2-iodoethoxy)-2-methoxybenzene
• CAS NO: 1187921-84-1
• Molecular Weight: 278.09
• Mol File: 1187921-84-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2-iodoethoxy)-2-methoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-iodoethoxy)-2-methoxybenzene(1187921-84-1)
• EPA Substance Registry System: 1-(2-iodoethoxy)-2-methoxybenzene(1187921-84-1)

Safety Data

• Hazardous Substances Data: 1187921-84-1(Hazardous Substances Data)

Upstream product

• 90-05-1 2-methoxy-phenol 

Downstream Products

• 180987-80-8 5-(((9H-carbazol-4-yl)oxy)methyl)-3-(2-(2-methoxyphenoxy)ethyl)oxazolidin-2-one 
• 72956-09-3 carvedilol 

Relevant articles and documents

Synthesis of racemic and chiral Carvedilol starting from corresponding 5-(chloromethyl)oxazolidin-2-one

The synthesis of racemic Carvedilol ((±)-1) has been achieved starting from 2-(chloromethyl) oxirane ((±)-2) in a four-step sequence. 5-(Chloromethyl) oxazolidin-2-one ((±)-3) and 5-((9Hcarbazol-4-yloxy) methyl) oxazolidin-2-one ((±)-4) are intermediates. A similar sequence starting from (R)- or (S)-2-(chloromethyl)oxirane 2 give corresponding chiral 5-((9Hcarbazol-4-yloxy)methyl) oxazolidin-2-one 4 followed by chiral Carvedilol 1. The synthetic sequence followed avoids the formation of impurity B (bis impurity). This approach can be useful for the preparation of pharmaceutically important moieties containingβ-amino alcohols without formation of bis impurity.