1187968-75-7 Usage
Uses
6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazol-3-amine can be used as reactant/reagent along with other materials for preparation of phosphoinositide 3-kinase inhibition, and pharmacokinetics of pyrrolopyrimidines.
Check Digit Verification of cas no
The CAS Registry Mumber 1187968-75-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,7,9,6 and 8 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1187968-75:
(9*1)+(8*1)+(7*8)+(6*7)+(5*9)+(4*6)+(3*8)+(2*7)+(1*5)=227
227 % 10 = 7
So 1187968-75-7 is a valid CAS Registry Number.
1187968-75-7Relevant articles and documents
An amino-indazole scaffold with spectrum selective kinase inhibition of FLT3, PDGFRα and kit
Deng, Xianming,Zhou, Wenjun,Weisberg, Ellen,Wang, Jinhua,Zhang, Jianming,Sasaki, Takaaki,Nelson, Erik,Griffin, James D.,Jaenne, Pasi A.,Gray, Nathanael S.
, p. 4579 - 4584 (2012/08/07)
Here we describe the synthesis and characterization of a number of 3-amino-1H-indazol-6-yl-benzamides that were designed to target the 'DFG-out' conformation of the kinase activation loop. Several compounds such as 4 and 11 exhibit single-digit nanomolar EC50s against FLT3, c-Kit and the gatekeeper T674M mutant of PDGFRα.
