1187968-75-7 Usage
Uses
Used in Pharmaceutical Industry:
6-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-3-aMino-1H-indazole is used as a reactant/reagent for the preparation of phosphoinositide 3-kinase (PI3K) inhibitors. PI3K plays a crucial role in cellular processes such as cell growth, survival, and metabolism, and its dysregulation is associated with various diseases, including cancer. By inhibiting PI3K, 6-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-3-aMino-1H-indazole may contribute to the development of novel therapeutics for treating these conditions.
Additionally, 6-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-3-aMino-1H-indazole is used in the study of pharmacokinetics of pyrrolopyrimidines. Understanding the pharmacokinetic properties of these compounds is essential for optimizing their drug delivery and efficacy, ultimately leading to the development of more effective treatments for various diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 1187968-75-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,7,9,6 and 8 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1187968-75:
(9*1)+(8*1)+(7*8)+(6*7)+(5*9)+(4*6)+(3*8)+(2*7)+(1*5)=227
227 % 10 = 7
So 1187968-75-7 is a valid CAS Registry Number.
1187968-75-7Relevant academic research and scientific papers
An amino-indazole scaffold with spectrum selective kinase inhibition of FLT3, PDGFRα and kit
Deng, Xianming,Zhou, Wenjun,Weisberg, Ellen,Wang, Jinhua,Zhang, Jianming,Sasaki, Takaaki,Nelson, Erik,Griffin, James D.,Jaenne, Pasi A.,Gray, Nathanael S.
, p. 4579 - 4584 (2012/08/07)
Here we describe the synthesis and characterization of a number of 3-amino-1H-indazol-6-yl-benzamides that were designed to target the 'DFG-out' conformation of the kinase activation loop. Several compounds such as 4 and 11 exhibit single-digit nanomolar EC50s against FLT3, c-Kit and the gatekeeper T674M mutant of PDGFRα.
