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118797-71-0

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118797-71-0 Usage

General Description

4',5'-dimethylfluorescein is a green fluorescent dye commonly used in biological and biochemical research. It belongs to the family of xanthene dyes and is often used as a pH indicator due to its ability to change color depending on the pH of the solution. Its fluorescent properties make it useful for labeling and imaging various cellular and molecular structures, including proteins and nucleic acids. 4',5'-dimethylfluorescein is also used in flow cytometry, immunohistochemistry, and fluorescence microscopy. Due to its stability, brightness, and low toxicity, it has become a widely used tool in the field of biological and medical research.

Check Digit Verification of cas no

The CAS Registry Mumber 118797-71-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,8,7,9 and 7 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 118797-71:
(8*1)+(7*1)+(6*8)+(5*7)+(4*9)+(3*7)+(2*7)+(1*1)=170
170 % 10 = 0
So 118797-71-0 is a valid CAS Registry Number.

118797-71-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 3',6'-dihydroxy-4',5'-dimethylspiro[2-benzofuran-3,9'-xanthene]-1-one

1.2 Other means of identification

Product number -
Other names 4',5'-Dimethylfluorescein

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:118797-71-0 SDS

118797-71-0Relevant articles and documents

Synthesis and evaluation of intrinsic bioactivity of fluorescein and phenolphthalein derivatives

Bharathkumar, Kuruba,Durairaj, Arulappan,Mohanapriya, Raman,Obadiah, Asir,Ramanathan, Subramanian,Santhoshkumar, Palanichamy,Vasanthkumar, Samuel

, (2021/09/28)

Fluorescein and phenolphthalein derivatives have been synthesized and screened for their bioactivity via molecular docking, cytotoxicity and antioxidant studies. In molecular docking studies, the compounds 3d have exhibited better glide score and hydrogen bonding ability when docked with t-RNA Dimethylallyltransferase. Antioxidant capabilities were evaluated via DPPH and ABTS radical scavenging activity. In this screening, compound 3d exhibited better inhibition efficiency in the DPPH and ABTS methods. Cytotoxicity of the compounds was assessed by the cell sustainability assay against human cervical cancer cell line (HeLa). All the synthesized compounds exhibited cytotoxic effects against HeLa cells and compounds 3d displayed better activity (IC50) than the standard drug (doxorubicin).

High purity phthalein derivatives and method for preparing same

-

Page/Page column 6, (2008/06/13)

The invention concerns high purity phthalcin derivatives enabling their use for medical applications or in the field of biotechnology, as well as their preparation method whereby a phthatic anhydride derivative is condensed with a naphthol or phenol derivative in an organic acid ester and the crystals of the resulting condensate are converted by action of a strong acid or one of its precursors in anhydrous medium.

Fluorescent sensors for Zn2+ based on a fluorescein platform: Synthesis, properties and intracellular distribution

Burdette,Walkup,Spingler,Tsien,Lippard

, p. 7831 - 7841 (2007/10/03)

Two new fluorescent sensors for Zn2+ that utilize fluorescein as a reporting group, Zinpyr-1 and Zinpyr-2, have been synthesized and characterized. Zinpyr-1 is prepared in one step via a Mannich reaction, and Zinpyr-2 is obtained in a multistep synthesis that utilizes 4′,5′-fluorescein dicarboxaldehyde as a key intermediate. Both Zinpyr sensors have excitation and emission wavelengths in the visible range (~500 nm), dissociation constants (Kd1) for Zn2+ of 2+ cation to the sensor, which inhibits a photoinduced electron transfer (PET) quenching pathway. The X-ray crystal structure of a 2:1 Zn2+:Zinpyr-1 complex has also been solved, and is the first structurally characterized example of a complex of fluorescein substituted with metal binding ligands.

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