Cas 1187975-74-1,5-oxo-2-phenethyltetrahydrofuran-2-carboxylic acid [3-(methanesulfonylmethylamino)-5-((R)-1-phenylethylcarbamoyl)phenyl]amide

1187975-74-1

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Basic information

Product Name: 5-oxo-2-phenethyltetrahydrofuran-2-carboxylic acid [3-(methanesulfonylmethylamino)-5-((R)-1-phenylethylcarbamoyl)phenyl]amide
Synonyms:
CAS NO:1187975-74-1
Molecular Formula:
Molecular Weight: 563.675
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 5-oxo-2-phenethyltetrahydrofuran-2-carboxylic acid [3-(methanesulfonylmethylamino)-5-((R)-1-phenylethylcarbamoyl)phenyl]amide(CAS DataBase Reference)
NIST Chemistry Reference: 5-oxo-2-phenethyltetrahydrofuran-2-carboxylic acid [3-(methanesulfonylmethylamino)-5-((R)-1-phenylethylcarbamoyl)phenyl]amide(1187975-74-1)
EPA Substance Registry System: 5-oxo-2-phenethyltetrahydrofuran-2-carboxylic acid [3-(methanesulfonylmethylamino)-5-((R)-1-phenylethylcarbamoyl)phenyl]amide(1187975-74-1)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 1187975-74-1(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1187975-74-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,7,9,7 and 5 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1187975-74:
(9*1)+(8*1)+(7*8)+(6*7)+(5*9)+(4*7)+(3*5)+(2*7)+(1*4)=221
221 % 10 = 1
So 1187975-74-1 is a valid CAS Registry Number.

1187975-74-1Upstream product

1187976-09-5 3-amino-5-(methanesulfonyl(methyl)amino)-N-((R)-1-phenylethyl)benzamide

1187975-74-1Downstream Products

1187975-78-5 2-hydroxy-2-phenethylpentanedioic acid 5-[((S)-1-benzylcarbamoyl-2-methylpropyl)amide] 1-{[3-(methanesulfonyl(methyl)amino)-5-((R)-1-phenylethylcarbamoyl)phenyl]amide}

1187975-74-1Relevant academic research and scientific papers

Design and synthesis of BACE-1 inhibitors utilizing a tertiary hydroxyl motif as the transition state mimic

Wangsell, Fredrik,Russo, Francesco,Saevmarker, Jonas,Rosenquist, Asa,Samuelsson, Bertil,Larhed, Mats

supporting information; experimental part, p. 4711 - 4714 (2010/04/28)

Two series of drug-like BACE-1 inhibitors with a shielded tertiary hydroxyl as transition state isostere have been synthesized. The most potent inhibitor exhibited a BACE-1 IC50 value of 0.23 μM.

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