Cas 1187976-01-7,(R)-2-benzyl-2-hydroxypentanedioic acid 1-[((1S,2R)-2-hydroxyindan-1-yl)amide] 5-{[3-(methanesulfonyl(methyl)amino)-5-((R)-1-phenylethylcarbamoyl)phenyl]amide}

1187976-01-7

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Basic information

Product Name: (R)-2-benzyl-2-hydroxypentanedioic acid 1-[((1S,2R)-2-hydroxyindan-1-yl)amide] 5-{[3-(methanesulfonyl(methyl)amino)-5-((R)-1-phenylethylcarbamoyl)phenyl]amide}
Synonyms: (R)-2-benzyl-2-hydroxypentanedioic acid 1-[((1S,2R)-2-hydroxyindan-1-yl)amide] 5-{[3-(methanesulfonyl(methyl)amino)-5-((R)-1-phenylethylcarbamoyl)phenyl]amide}
CAS NO:1187976-01-7
Molecular Formula:
Molecular Weight: 698.84
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: (R)-2-benzyl-2-hydroxypentanedioic acid 1-[((1S,2R)-2-hydroxyindan-1-yl)amide] 5-{[3-(methanesulfonyl(methyl)amino)-5-((R)-1-phenylethylcarbamoyl)phenyl]amide}(CAS DataBase Reference)
NIST Chemistry Reference: (R)-2-benzyl-2-hydroxypentanedioic acid 1-[((1S,2R)-2-hydroxyindan-1-yl)amide] 5-{[3-(methanesulfonyl(methyl)amino)-5-((R)-1-phenylethylcarbamoyl)phenyl]amide}(1187976-01-7)
EPA Substance Registry System: (R)-2-benzyl-2-hydroxypentanedioic acid 1-[((1S,2R)-2-hydroxyindan-1-yl)amide] 5-{[3-(methanesulfonyl(methyl)amino)-5-((R)-1-phenylethylcarbamoyl)phenyl]amide}(1187976-01-7)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 1187976-01-7(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1187976-01-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,7,9,7 and 6 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1187976-01:
(9*1)+(8*1)+(7*8)+(6*7)+(5*9)+(4*7)+(3*6)+(2*0)+(1*1)=207
207 % 10 = 7
So 1187976-01-7 is a valid CAS Registry Number.

1187976-01-7Upstream product

1187975-94-5 (R)-2-benzyl-2-(tert-butyldimethylsilanyloxy)pentanedioic acid 1-{[(1S,2R)-2-(tert-butyldimethylsilanyloxy)indan-1-yl]amide} 5-{[3-(methanesulfonyl(methyl)amino)-5-((R)-1-phenylethylcarbamoyl)phenyl]amide}

1187976-01-7Downstream Products

1187976-01-7Relevant academic research and scientific papers

Design and synthesis of BACE-1 inhibitors utilizing a tertiary hydroxyl motif as the transition state mimic

Wangsell, Fredrik,Russo, Francesco,Saevmarker, Jonas,Rosenquist, Asa,Samuelsson, Bertil,Larhed, Mats

supporting information; experimental part, p. 4711 - 4714 (2010/04/28)

Two series of drug-like BACE-1 inhibitors with a shielded tertiary hydroxyl as transition state isostere have been synthesized. The most potent inhibitor exhibited a BACE-1 IC50 value of 0.23 μM.

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