1188002-12-1

Basic information

• Product Name: 5,7-difluoro-6-iodo-4-phenyl-3,4-dihydroquinolin-2-one
• CAS NO: 1188002-12-1
• Molecular Weight: 385.152
• Mol File: 1188002-12-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5,7-difluoro-6-iodo-4-phenyl-3,4-dihydroquinolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-difluoro-6-iodo-4-phenyl-3,4-dihydroquinolin-2-one(1188002-12-1)
• EPA Substance Registry System: 5,7-difluoro-6-iodo-4-phenyl-3,4-dihydroquinolin-2-one(1188002-12-1)

Safety Data

• Hazardous Substances Data: 1188002-12-1(Hazardous Substances Data)

Relevant articles and documents

Synthesis of polyfluorinated 4-phenyl-3,4-dihydroquinolin-2-ones and quinolin-2-ones via superacidic activation of N-(polyfluorophenyl)cinnamamides

The cyclization reactions of a series of polyfluorocinnamanilides in triflic acid (CF3SO3H) yield 4-phenyl-3,4-dihydroquinolin-2-ones, which include a polyfluorinated benzene moiety as a part of the quinoline scaffold. These compounds undergo dehydrophenylation in the presence of AlCl3 to give the corresponding polyfluoroquinolin-2-ones which are converted into polyfluorinated 2-chloroquinolines on treatment with POCl3. A mechanism for the cyclization reaction presuming the intermediacy of a superelectrophilic O,C-diprotonated form of the starting material is suggested.