118801-71-1

Basic information

• Product Name: 6H-Pyrrolo[2,3-d]pyrimidin-6-one, 5,7-dihydro-2-methyl- (6CI,9CI)
• Synonyms: 6H-Pyrrolo[2,3-d]pyrimidin-6-one, 5,7-dihydro-2-methyl- (6CI,9CI)
• CAS NO: 118801-71-1
• Molecular Formula: C₇H₇N₃O
• Molecular Weight: 149.14998
• Product Categories: PYRIMIDINE
• Mol File: 118801-71-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6H-Pyrrolo[2,3-d]pyrimidin-6-one, 5,7-dihydro-2-methyl- (6CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 6H-Pyrrolo[2,3-d]pyrimidin-6-one, 5,7-dihydro-2-methyl- (6CI,9CI)(118801-71-1)
• EPA Substance Registry System: 6H-Pyrrolo[2,3-d]pyrimidin-6-one, 5,7-dihydro-2-methyl- (6CI,9CI)(118801-71-1)

Safety Data

• Hazardous Substances Data: 118801-71-1(Hazardous Substances Data)

Upstream product

• 98335-69-4 (4-amino-2-methyl-pyrimidin-5-yl)-acetic acid hydrazide 
• 14273-76-8 ethyl 2-(4-chloro-2-methylpyrimidin-5-yl)acetate 
• 14273-42-8 ethyl 2-(4-hydroxy-2-methylpyrimidin-5-yl)acetate 
• 5472-38-8 diethyl 2-formylbutanedioate 
• 42981-14-6 2-(4-amino-2-methylpyrimidin-5-yl)acetamide 
• 220895-93-2 (4-amino-2-methyl-pyrimidin-5-yl)-acetic acid ethyl ester 

Relevant articles and documents

Convenient synthesis of 2-substituted 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-ones

A new synthetic route was elaborated at our laboratory providing a convenient access to 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-ones (diazaoxindoles), a compound family of biological relevance. Treatment of the easily available ethyl 2-(4-chloropyrimidin-5-yl)acetate derivatives with ammonia afforded the corresponding 2-(4-aminopyrimidin-5-yl)acetamides, which were finally cyclized to the target compounds.

Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors

Methods of treating one or more conditions associated with p38 kinase activity are disclosed comprising administering to a patient in need thereof at least one compound having the formula (I): 1or a pharmaceutically acceptable salt, prodrug, or solvate thereof, wherein R3 is hydrogen, methyl, perfluoromethyl, methoxy, halogen, cyano, or NH2, preferably methyl, and X, R1 through R6, and Z are as described in the specification. Advantageously the groups —ZR4R5 taken together comprise an —NH-substituted aryl.