118808-13-2

Usage

Uses

Used in Pharmaceutical Industry:
[2-(azepan-1-yl)ethyl](methyl)amine is used as a building block for the synthesis of potential drug candidates due to its unique chemical structure and properties. It contributes to the development of new medications with specific therapeutic effects.
Used in Chemical Synthesis:
[2-(azepan-1-yl)ethyl](methyl)amine is used as a key component in the synthesis of other complex organic molecules. Its versatile nature allows it to be integrated into various chemical processes, leading to the creation of a wide range of products with different applications across various industries.
Overall, [2-(azepan-1-yl)ethyl](methyl)amine holds promise for several industrial and research applications, thanks to its distinctive chemical structure and properties.

Upstream product

• 138357-14-9 (2-Azepan-1-yl-2-oxo-ethyl)-carbamic acid tert-butyl ester 
• 111-49-9 hexamethylene imine 

Downstream Products

• 138357-16-1 N-(2-Azepan-1-yl-ethyl)-2-(3,4-dichloro-phenyl)-N-methyl-acetamide 
• 138356-42-0 LR 172 

Relevant academic research and scientific papers

Asymmetric synthesis catalyzed by chiral ferrocenylphosphine transition metal complexes. 10 gold(I)-catalyzed asymmetric aldol reaction of isocyanoacetate

Optically active ferrocenylbisphosphine ligands containing 2-(dialkylamino)ethylamino group on the ferrocenylmethyl position have been prepared and used for the gold(I)-catalyzed asymmetric aldol reaction of isocyanoacetate with aldehydes. Six-membered ring amines, such as morpholino or piperidino group, at the terminal of the side chain were most stereoselective to give optically active trans-4- methoxycarbonyl-5-alkyl-2-oxazolines (up to 97% ee) with high enantio- and diastereoselectivity in a quantitative yield.

Synthesis, characterization, and biological evaluation of a novel class of N-(arylethyl)-N-alkyl-2-(1-pyrrolidinyl)ethylamines: Structural requirements and binding affinity at the σ receptor

By synthesizing and testing a part-structure, N-[2-(3,4- dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamine (3), derived from our previously reported high affinity σ receptor ligands (1S,2R)-(-)-N-[2- (3,4-dichlorophenyl)-ethyl]-N-methyl-2-(1-pyrrolidinyl)cyclohexylamine [(-)- 2] and (+)-2, we have identified a novel class of superpotent (subnanomolar affinity) σ ligands specific for the σ receptor labeled by [3H]-(+)-3-PPP. When 3 was tested for its capacity to displace [3H]-(+)-3-PPP from guinea pig brain membranes, it exhibited a K(i) of 0.34 nM, which is better than either of its parent compounds (-)-2 (K(i) = 1.3 nM) and (+)-2 (K(i) = 6.0 nM). Other compounds related to 3 such as N-[2-(3,4-dichlorophenyl)ethyl]-N- methyl-2-(1-homopiperidinyl)ethylamine (19) exhibited K(i) = 0.17 nM ([3H]- (+)-3-PPP). The determinants for high σ receptor affinity of 3 were examined by manipulation of this structure in a number of different ways. The high efficacy of these compounds for the σ receptor, their relative chemical simplicity and ease of synthesis, and their high degree of selectivity identifies N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1- pyrrolidinyl)ethylamine (3) and related compounds as a highly promising base for determination of the functional role of σ receptors as well as the development of novel therapeutic agents.