118808-13-2

Basic information

• Product Name: [2-(azepan-1-yl)ethyl](methyl)amine
• Synonyms: [2-(azepan-1-yl)ethyl](methyl)amine
• CAS NO: 118808-13-2
• Molecular Formula: C₉H₂₀N₂
• Molecular Weight: 156.2685
• Mol File: 118808-13-2.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [2-(azepan-1-yl)ethyl](methyl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(azepan-1-yl)ethyl](methyl)amine(118808-13-2)
• EPA Substance Registry System: [2-(azepan-1-yl)ethyl](methyl)amine(118808-13-2)

Safety Data

• Hazardous Substances Data: 118808-13-2(Hazardous Substances Data)

Usage

General Description

[2-(azepan-1-yl)ethyl](methyl)amine is a chemical compound that consists of an aminoethyl group attached to the azepane ring and a methyl group. It is a derivative of amine that can be used in various chemical reactions and synthesis processes. The compound has potential applications in pharmaceuticals, such as in the synthesis of potential drug candidates. Additionally, it can be used as a building block in the production of other complex organic molecules. Overall, the compound has the potential for several industrial and research applications due to its unique chemical structure and properties.

Upstream product

• 111-49-9 hexamethylene imine 
• 138357-14-9 (2-Azepan-1-yl-2-oxo-ethyl)-carbamic acid tert-butyl ester 

Downstream Products

• 138356-42-0 LR 172 
• 138357-16-1 N-(2-Azepan-1-yl-ethyl)-2-(3,4-dichloro-phenyl)-N-methyl-acetamide 

Relevant articles and documents

Synthesis, characterization, and biological evaluation of a novel class of N-(arylethyl)-N-alkyl-2-(1-pyrrolidinyl)ethylamines: Structural requirements and binding affinity at the σ receptor

By synthesizing and testing a part-structure, N-[2-(3,4- dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamine (3), derived from our previously reported high affinity σ receptor ligands (1S,2R)-(-)-N-[2- (3,4-dichlorophenyl)-ethyl]-N-methyl-2-(1-pyrrolidinyl)cyclohexylamine [(-)- 2] and (+)-2, we have identified a novel class of superpotent (subnanomolar affinity) σ ligands specific for the σ receptor labeled by [3H]-(+)-3-PPP. When 3 was tested for its capacity to displace [3H]-(+)-3-PPP from guinea pig brain membranes, it exhibited a K(i) of 0.34 nM, which is better than either of its parent compounds (-)-2 (K(i) = 1.3 nM) and (+)-2 (K(i) = 6.0 nM). Other compounds related to 3 such as N-[2-(3,4-dichlorophenyl)ethyl]-N- methyl-2-(1-homopiperidinyl)ethylamine (19) exhibited K(i) = 0.17 nM ([3H]- (+)-3-PPP). The determinants for high σ receptor affinity of 3 were examined by manipulation of this structure in a number of different ways. The high efficacy of these compounds for the σ receptor, their relative chemical simplicity and ease of synthesis, and their high degree of selectivity identifies N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1- pyrrolidinyl)ethylamine (3) and related compounds as a highly promising base for determination of the functional role of σ receptors as well as the development of novel therapeutic agents.