1188265-06-6

Basic information

• Product Name: ETHYL 7-(4-METHOXYPHENYL)-4,7-DIOXOHEPTANOATE
• Synonyms: ETHYL 7-(4-METHOXYPHENYL)-4,7-DIOXOHEPTANOATE;4,7-Dioxo-7-(4-methoxyphenyl)heptanoic acid ethyl ester;4-Methoxy-gamma,zeta-dioxobenzeneheptanoic acid ethyl ester
• CAS NO: 1188265-06-6
• Molecular Formula: C₁₆H₂₀O₅
• Molecular Weight: 292.327
• Mol File: 1188265-06-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.119
• CAS DataBase Reference: ETHYL 7-(4-METHOXYPHENYL)-4,7-DIOXOHEPTANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 7-(4-METHOXYPHENYL)-4,7-DIOXOHEPTANOATE(1188265-06-6)
• EPA Substance Registry System: ETHYL 7-(4-METHOXYPHENYL)-4,7-DIOXOHEPTANOATE(1188265-06-6)

Safety Data

• Hazardous Substances Data: 1188265-06-6(Hazardous Substances Data)

Usage

General Description

ETHYL 7-(4-METHOXYPHENYL)-4,7-DIOXOHEPTANOATE is a chemical compound that belongs to the family of esters. It is derived from the reaction between ethyl alcohol and 7-(4-methoxyphenyl)-4,7-dioxoheptanoic acid. It is commonly used as a flavoring agent in food and beverages, as well as in the production of perfumes and beauty products. The compound has a fruity and sweet aroma, making it a popular choice for adding fragrance to various products. In addition, it is also used in pharmaceuticals and other industrial applications, making it a versatile and widely-used chemical compound.

Upstream product

• 98-01-1 furfural 
• 64-17-5 ethanol 
• 114570-69-3 3-(2-furyl)-1-(4-methoxyphenyl)propen-1-one 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 5066-65-9 (E)-3-(furan-2-yl)-1-(4-methoxyphenyl)prop-2-en-1-one 

Downstream Products

• 833434-89-2 C₂₁H₂₀N₂O₄ 
• 1208315-32-5 3-(1-(4-carbamoyl-2-methylphenyl)-5-(4-methoxyphenyl)-1H-pyrrol-2-yl)propanoic acid 
• 1208317-98-9 3-[1-(4-carbamoyl-2-methylphenyl)-5-(4-methoxyphenyl)-1H-pyrrol-2-yl]propanoic acid ethyl ester 
• 1208318-42-6 ethyl 3-(1-(4-(dimethylcarbamoyl)-2-methylphenyl)-5-(4-methoxyphenyl)-1H-pyrrol-2-yl)propanoate 
• 1208318-49-3 C₂₈H₂₈N₄O₄ 
• 1208318-71-1 C₂₉H₂₉N₃O₄ 
• 1366233-14-8 C₂₄H₂₇NO₄ 
• 1366233-08-0 C₂₄H₂₆N₂O₄ 
• 1208318-74-4 ethyl 3-(1-(4-bromophenyl)-5-(4-methoxyphenyl)-1H-pyrrol-2-yl)propanoate 
• 1366233-13-7 C₂₄H₂₇NO₃ 
• 1366233-05-7 C₂₃H₂₅NO₄ 
• 1366233-07-9 C₂₄H₂₅NO₄ 
• 1366233-20-6 C₂₉H₂₉N₃O₄ 
• 1366233-10-4 C₂₄H₂₆N₂O₄ 

Relevant articles and documents

Pyrrole inhibitors of S-nitrosoglutathione reductase as therapeutic agents

The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.

Discovery of S-nitrosoglutathione reductase inhibitors: Potential agents for the treatment of asthma and other inflammatory diseases

S-Nitrosoglutathione reductase (GSNOR) regulates S-nitrosothiols (SNOs) and nitric oxide (NO) in vivo through catabolism of S-nitrosoglutathione (GSNO). GSNOR and the anti-inflammatory and smooth muscle relaxant activities of SNOs, GSNO, and NO play significant roles in pulmonary, cardiovascular, and gastrointestinal function. In GSNOR knockout mice, basal airway tone is reduced and the response to challenge with bronchoconstrictors or airway allergens is attenuated. Consequently, GSNOR has emerged as an attractive therapeutic target for several clinically important human diseases. As such, small molecule inhibitors of GSNOR were developed. These GSNOR inhibitors were potent, selective, and efficacious in animal models of inflammatory disease characterized by reduced levels of GSNO and bioavailable NO. N6022, a potent and reversible GSNOR inhibitor, reduced bronchoconstriction and pulmonary inflammation in a mouse model of asthma and demonstrated an acceptable safety profile. N6022 is currently in clinical development as a potential agent for the treatment of acute asthma.