1188296-52-7

Basic information

• Product Name: PF 4800567 hydrochloride
• Synonyms: 3-[(3-Chlorophenoxy)Methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine Hydrochloride;PF 4800567;3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;PF 4800567 hydrochloride;3-[(3-chlorophenoxy)methyl]-1-(oxan-4-yl)pyrazolo[3,4-d]pyrimidin-4-amine
• CAS NO: 1188296-52-7
• Molecular Formula: C17H19Cl2N5O2
• Molecular Weight: 396.27106
• Mol File: 1188296-52-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 592.9±50.0 °C(Predicted)
• Appearance: /
• Density: 1.52±0.1 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 4.01±0.30(Predicted)
• CAS DataBase Reference: PF 4800567 hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: PF 4800567 hydrochloride(1188296-52-7)
• EPA Substance Registry System: PF 4800567 hydrochloride(1188296-52-7)

Safety Data

• Hazardous Substances Data: 1188296-52-7(Hazardous Substances Data)

Usage

Description

PF 4800567 hydrochloride, also known as PF-4800567, is a selective inhibitor of casein kinase 1ε (CK1ε) with an IC50 value of 32 nM. It exhibits greater than 20-fold selectivity over CK1δ and is an ATP competitive inhibitor. PF 4800567 hydrochloride is used in the study of CK1 enzymes in the regulation of circadian rhythm and has been reported to have neuroprotective effects.

Uses

Used in Pharmaceutical Research:
PF 4800567 hydrochloride is used as a selective casein kinase 1ε inhibitor for studying the role of CK1 enzymes in the regulation of circadian rhythms in cells. Its high potency and selectivity make it a valuable tool in understanding the molecular mechanisms underlying circadian rhythm disorders.
Used in Neuroprotection:
PF 4800567 hydrochloride is used as a neuroprotective agent due to its reported neuroprotective effects. It may have potential applications in the treatment of neurodegenerative diseases and conditions associated with impaired circadian rhythms.
Used in Drug Development:
PF 4800567 hydrochloride is used as a lead compound in the development of new drugs targeting casein kinase 1ε. Its selectivity and potency make it a promising candidate for the creation of therapeutic agents that can modulate circadian rhythm regulation and provide neuroprotection.