1188296-91-4Relevant academic research and scientific papers
A gold-catalyzed 1,2-acyloxy migration/intramolecular cyclopropanation/ring enlargement cascade: Syntheses of medium-sized heterocycles
Sun, Yin-Wei,Tang, Xiang-Ying,Shi, Min
, p. 13937 - 13940 (2015/09/07)
The synthesis of medium-sized heterocycles possessing a trans double bond is still a challenge. Herein, gold(I)-catalyzed 1,2-acyloxy migration/intramolecular cyclopropanation/ring enlargement cascade reaction of furans has been developed, providing highly efficient access to ten- and eleven-membered heterocycles with a broad substrate scope under mild reaction conditions. The reaction outcome features high chemoselectivity at the C5-position of furan. Moreover, a trans-double bond was embodied in the medium ring system.
Gold catalysis: Switching the pathway of the furan-yne cyclization
Hashmi, A. Stephen K.,Rudolph, Matthias,Huck, Juergen,Frey, Wolfgang,Bats, Jan W.,Hamzic, Melissa
supporting information; experimental part, p. 5848 - 5852 (2009/12/06)
Changing tracks: By the use of alkynyl ethers as directing elements, the furan-yne cyclization enters a new reaction pathway. Instead of phenols, tetracycles containing two heteroatoms and two new stereocenters are formed (see scheme).
