1188391-13-0Relevant articles and documents
Water-soluble phosphate prodrugs of pleuromutilin analogues with potent in vivo antibacterial activity against Gram-positive pathogens
Fu, Liqiang,Jiang, Zhiteng,cai, Zhan,Liu, Xin,He, Huili,Yang, Yushe
, p. 5407 - 5410 (2009)
A phosphate prodrug strategy was investigated to address the problem of poor aqueous solubility of pleuromutilin analogues. Water-soluble phosphate prodrugs 6a, 6b and 6c of pleuromutilin analogues were designed and synthesized. Three compounds all exhibi