1188392-65-5Relevant articles and documents
Design, synthesis and evaluation of tetrahydroisoquinolines as new kinesin spindle protein inhibitors
Jiang, Cheng,You, Qidong,Liu, Fei,Wu, Wutong,Guo, Qinglong,Chern, Jiwang,Yang, Lei,Chen, Mengling
experimental part, p. 567 - 571 (2009/12/28)
In this study, a series of tetrahydroisoquinolines have been synthesized and identified as novel kinesine spindle protein (KSP) inhibitors based on the pharmacophore we have mapped and the crystal structure of monastrol bound to the target protein. The KS